The 12th International Sustainability Transitions Conference (IST) will be hosted from Karlsruhe, Germany from October 5 to 8, 2021. The IST is the central event of the international transitions research community and is organized annually by different partners on behalf of the Sustainability Transitions Research Network (STRN). STRN comprises more than 1500 international researchers from various disciplines and produces more than 500 publications in specialist journals every year. The research network and the annual conference address the question of how the transition to sustainability can succeed through co-evolutionary changes and innovations in socio-technical systems. IST 2021 is hosted by Fraunhofer Institute for Systems and Innovation Research ISI.